Zacharieva S, Stoeva I, Andreeva M, Kalinov K, Matrozov P, Andonova K
Clinical Center of Endocrinology and Gerontology, Sofia, Bulgaria.
Methods Find Exp Clin Pharmacol. 1996 Nov;18(9):593-7.
The acute effect of 10 mg metoclopramide i.v. on prolactin and aldosterone levels was studied in 8 women with prolactinoma and 8 normal women. The prolactin response to metoclopramide was blunted in hyperprolactinemic patients in comparison with controls. Metoclopramide induced similar aldosterone increases in patients and controls, but hyperprolactinemic women showed a more sustained aldosterone response. Bromocriptine treatment (10 mg daily p.o. for 5 days) in patients with prolactinoma completely suppressed the prolactin response to metoclopramide and the aldosterone response curve was very similar to that of controls. The results did not exclude some degree of suppression of aldosterone in response to bromocriptine.
对8名患有催乳素瘤的女性和8名正常女性研究了静脉注射10毫克甲氧氯普胺对催乳素和醛固酮水平的急性影响。与对照组相比，高催乳素血症患者对甲氧氯普胺的催乳素反应减弱。甲氧氯普胺在患者和对照组中引起相似的醛固酮升高，但高催乳素血症女性的醛固酮反应更持久。对催乳素瘤患者进行溴隐亭治疗（口服每日10毫克，共5天）可完全抑制对甲氧氯普胺的催乳素反应，且醛固酮反应曲线与对照组非常相似。结果并未排除溴隐亭对醛固酮有一定程度的抑制作用。
