Schnur M J, Appel G B, Bilezikian J P
Arch Intern Med. 1977 Sep;137(9):1201-3.
Three patients had primary hyperparathyroidism and monoclonal serum immunoglobulins. Although multiple myeloma was suspected in each case, subsequent evaluation was consistent with a "benign monoclonal gammopathy". Parathyroid adenomas were removed from two patients. The three patients are presented and compared to the four other cases that have been reported previously. The association between primary hyperparathyroidism and benign monoclonal gammopathy is discussed in terms of possible pathogenetic mechanisms. Primary hyperparathyroidism should be suspected in patients with hypercalcemia and benigh monoclonal gammopathy, as well as in other conditions, like multiple myeloma, that are known to be associated with hypercalcemia.
三名患者患有原发性甲状旁腺功能亢进症和单克隆血清免疫球蛋白。尽管在每例病例中都怀疑有多发性骨髓瘤，但随后的评估结果与“良性单克隆丙种球蛋白病”相符。两名患者接受了甲状旁腺腺瘤切除术。本文介绍了这三名患者，并与之前报道的其他四例病例进行了比较。从可能的发病机制方面讨论了原发性甲状旁腺功能亢进症与良性单克隆丙种球蛋白病之间的关联。对于高钙血症和良性单克隆丙种球蛋白病患者，以及其他已知与高钙血症相关的疾病（如多发性骨髓瘤）患者，均应怀疑原发性甲状旁腺功能亢进症。
