Raś A, Janowski T, Zduńczyk S
Lehrstuhl für Geburtshilfe und Pathologie der Fortpflanzung, Veterinärmedizinischen Fakultät, Agrar-Technischen Universität Olsztyn, Polen.
Tierarztl Prax. 1996 Aug;24(4):347-52.
Experiment 1: In a field experiment in 19 of 87 cows being in day 260-265 of pregnancy subclinical metabolic acidosis was found. The control group included 10 healthy cows in the same stage of pregnancy. Blood samples from cows of both groups were collected once daily until day 2 post partum for determination of oestrogens, progesterone and cortisol. Dystocia was found in four and retained placenta in three cows having acidosis. These cows had lower oestrogens and markedly higher cortisol and progesterone concentrations during parturition. Course of pregnancy and delivery in control cows an without any difficulties and hormonal profiles in these cows were typical. Experiment 2: On day 265 of pregnancy experimental acute acidosis was evoked in five cows and five other cows served as control. Sampling of blood was the same as in experiment 1. Acidosis caused on day 269 in two cows premature birth with retained placenta. Moreover concentrations of studied steroids were atypical. In three other cows with acidosis course of pregnancy and delivery was without any trouble. Only cortisol was increased while progesterone and oestrogen values were in agreement with concentrations of control cows. Data suggest that metabolic acidosis can cause dystocia, premature birth and retained placenta. Furthermore, acidosis clearly affects the profile of steroid hormones.
实验1：在一项实地实验中，87头处于妊娠第260 - 265天的奶牛中有19头被发现患有亚临床代谢性酸中毒。对照组包括10头处于相同妊娠阶段的健康奶牛。两组奶牛的血样每天采集一次，直至产后第2天，用于测定雌激素、孕酮和皮质醇。酸中毒的奶牛中有4头出现难产，3头出现胎盘滞留。这些奶牛在分娩期间雌激素水平较低，皮质醇和孕酮浓度明显较高。对照组奶牛的妊娠和分娩过程没有任何困难，这些奶牛的激素水平也很典型。实验2：在妊娠第265天，对5头奶牛诱发实验性急性酸中毒，另外5头奶牛作为对照。采血方式与实验1相同。在第269天，酸中毒导致2头奶牛早产并伴有胎盘滞留。此外，所研究的类固醇浓度不典型。另外3头酸中毒奶牛的妊娠和分娩过程没有任何问题。只有皮质醇升高，而孕酮和雌激素值与对照奶牛的浓度一致。数据表明，代谢性酸中毒可导致难产、早产和胎盘滞留。此外，酸中毒明显影响类固醇激素水平。
