Klee S, Nürnberger M C, Keller H, Ungemach F R
Institut für Pharmakologie und Toxikologie, FU Berlin.
Tierarztl Prax. 1996 Aug;24(4):368-72.
A therapeutical dose of kanamycin was tested intravenously and intramuscularly in four normal standardbreds and plasma concentrations were measured over a 12 hour period. Plasma levels exceeded a minimum inhibitory concentration of 4 micrograms/ml within only 15 minutes for 8 hours both after i.v. and i.m. injection. Kanamycin revealed a mean plasma half life of 2.3 hours. Bioavailability of an intramuscular dose was about 76%. The pharmacokinetic parameters demonstrate the rapid onset of antibacterial plasma levels of the test compound. A dose regimen for horses of two times daily 5 mg/kg body weight ensures therapeutically effective plasma levels. The risk of accumulation as well as nephro- or ototoxic side effects are negligible at short-term treatment.
对4匹正常的标准bred马静脉注射和肌肉注射治疗剂量的卡那霉素，并在12小时内测量血浆浓度。静脉注射和肌肉注射后仅15分钟内，血浆水平就超过了4微克/毫升的最低抑菌浓度，并在8小时内保持该水平。卡那霉素的平均血浆半衰期为2.3小时。肌肉注射剂量的生物利用度约为76%。药代动力学参数表明受试化合物的抗菌血浆水平起效迅速。马的给药方案为每日两次，每次5毫克/千克体重，可确保达到治疗有效的血浆水平。在短期治疗中，蓄积风险以及肾毒性或耳毒性副作用可忽略不计。
