Chase J P, Beard W L, Bertone A L, Goltz K
Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, USA.
Vet Surg. 1996 May-Jun;25(3):189-94. doi: 10.1111/j.1532-950x.1996.tb01397.x.
Peritonitis was induced in 12 horses by median celiotomy and 1 hour of small intestinal ischemia. Six horses had primary closure of the incision, whereas six horses had a plastic mesh sutured to the ventral abdominal wall leaving the abdomen open for ventral drainage. The mesh was removed after 5 days and the abdominal wall was closed by apposition of the linea alba and subcutaneous tissues and approximation ef the skin edges. Peritoneal fluid was collected and analyzed for nucleated cell count and total protein concentration on days 0 and 5. Serum biochemical profiles, serum electrolyte concentrations, and complete blood counts were performed on days 0, 1, 2, 5, 6, 10, and 14. Body weight, rectal temperature, and physical examination findings were recorded daily for 30 days, then horses were euthanatized and the abdominal cavity was examined for the presence of adhesions. Histological examination was performed to assess the inflammatory response of the healing body wall; inflammation scores were significantly lower in horses that had primary closure of the incision. The mesh was well tolerated by all horses and allowed egress of peritoneal fluid for 5 days. Adhesions were present in four control horses and in two horses that had open peritoneal drainage. All horses that had open drainage developed incisional infections after mesh removal. Abdominal wall herniation did not occur in any of the horses. The mild peritonitis induced in this study was insufficient to establish the efficacy of open peritoneal drainage for an established peritonitis in horses; however, the results of this study indicate that open peritoneal drainage is feasible in horses.
通过正中剖腹术和1小时的小肠缺血在12匹马中诱发腹膜炎。6匹马进行切口一期缝合，而6匹马则将塑料网缝合至腹前壁，使腹腔开放以进行腹腔引流。5天后取出网片，通过白线和皮下组织对合以及皮肤边缘对合关闭腹壁。在第0天和第5天收集腹腔液并分析有核细胞计数和总蛋白浓度。在第0、1、2、5、6、10和14天进行血清生化指标、血清电解质浓度和全血细胞计数检查。每天记录30天的体重、直肠温度和体格检查结果，然后对马实施安乐死并检查腹腔内有无粘连。进行组织学检查以评估愈合的体壁的炎症反应；切口一期缝合的马的炎症评分显著较低。所有马对网片耐受性良好，且网片使腹腔液排出5天。4匹对照马和2匹进行腹腔开放引流的马出现粘连。所有进行开放引流的马在取出网片后均发生切口感染。所有马均未发生腹壁疝。本研究中诱发的轻度腹膜炎不足以确定开放腹腔引流对马已确诊腹膜炎的疗效；然而，本研究结果表明开放腹腔引流在马中是可行的。
