Adams D B
Aust J Exp Biol Med Sci. 1977 Feb;55(1):49-57. doi: 10.1038/icb.1977.5.
The number of lymphocytes discharged from the mesenteric lymphatic duct was measured over several days of continuous lymph drainage in adult guinea pigs which had been thymectomised at birth or as young adults. The reduced output of lymphocytes during the first few days of lymph drainage from neonatally thymectomised guinea pigs indicated that removal of the thymus at birth produced a deficiency in the mobilizable lymphocyte pool. Adult thymectomy led to a decrease in the mobilizable lymphocyte pool which did not become apparent until 35 days after removal of the thymus. This indicated that the production of lymphocytes by the thymus is important in the guinea pig for maintaining adequate numbers of recirculating lymphocytes during adult life. The concentration of lymphocytes was reduced in the peripheral blood of guinea pigs which had been thymectomised at birth. In female guinea pigs this lymphopenia was accompanied by an increase in the number of lymphocytes bearing Kurloff bodies. The concentration of lymphocytes in bone marrow was not significantly altered following neonatal thymectomy.
在出生时或成年早期接受胸腺切除术的成年豚鼠中，通过连续几天的淋巴引流来测量从肠系膜淋巴管排出的淋巴细胞数量。新生期胸腺切除的豚鼠在淋巴引流的最初几天淋巴细胞输出减少，这表明出生时切除胸腺会导致可动员淋巴细胞库的缺乏。成年期胸腺切除导致可动员淋巴细胞库减少，这种减少直到切除胸腺35天后才变得明显。这表明胸腺产生淋巴细胞对于豚鼠在成年期维持足够数量的再循环淋巴细胞很重要。出生时接受胸腺切除术的豚鼠外周血中淋巴细胞浓度降低。在雌性豚鼠中，这种淋巴细胞减少伴随着带有库尔洛夫小体的淋巴细胞数量增加。新生期胸腺切除后骨髓中淋巴细胞浓度没有明显改变。
