卡维地洛和依布硒啉在体外对次氯酸的清除作用。
Scavenging of hypochlorous acid by carvedilol and ebselen in vitro.
作者信息
Aruoma O I
机构信息
Pharmacology Group, University Of London King's College, UK.
出版信息
Gen Pharmacol. 1997 Feb;28(2):269-72. doi: 10.1016/s0306-3623(96)00232-7.
PMID:9013206
Abstract
- The antihypertensive drug carvedilol and the antiinflammatory selenoorganic compound ebselen were tested for their ability to react with the reactive oxygen species hypochlorous acid (HOCl) in vitro. 2. Carvedilol scavenges HOCl at a rate sufficient to protect a model molecule catalase against inactivation by HOCl. 3. Ebselen was resistant to HOCl when its glutathione-peroxidase mimetic property was compared with that of glutathione peroxidase.
摘要
- 对降压药卡维地洛和抗炎性有机硒化合物依布硒仑在体外与活性氧次氯酸（HOCl）反应的能力进行了测试。2. 卡维地洛清除HOCl的速率足以保护模型分子过氧化氢酶不被HOCl灭活。3. 将依布硒仑的谷胱甘肽过氧化物酶模拟特性与谷胱甘肽过氧化物酶的特性进行比较时，发现依布硒仑对HOCl具有抗性。
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