Kawamoto S, Kanematsu E, Kanimoto Y, Kawada Y
Department of Nephrology, Social Insurance Saitama Chuo Hospital.
Hinyokika Kiyo. 1996 Dec;42(12):931-5.
We used 15-deoxyspergualin (DSG) to treat acute on chronic rejection (AOCR) in six kidney transplant recipients. DSG was administered intermittently at a dose of 200-300 mg per body every 2 or 4 weeks for more than 6 months. The efficacy of DSG was evaluated by the changes in serum creatinine values during the rejection therapy. Four (67%) of the six patients responded with the suppression of the increase in serum creatinine values. On the other hand, one patient did not respond at all and developed advanced pancytopenia. These findings suggested that intermittent administration of DSG would be efficient therapy on AOCR in the renal allografts if the patients were treated carefully to prevent severe side effects.
我们使用15-去氧精胍菌素（DSG）治疗6例肾移植受者的慢性排斥急性发作（AOCR）。DSG以每2或4周每体200 - 300毫克的剂量间歇给药，持续6个月以上。通过排斥治疗期间血清肌酐值的变化评估DSG的疗效。6例患者中有4例（67%）血清肌酐值升高得到抑制。另一方面，1例患者完全无反应并出现严重全血细胞减少。这些发现表明，如果对患者进行仔细治疗以预防严重副作用，间歇性给予DSG对肾移植中的AOCR将是有效的治疗方法。
