Büttner T, Kuhn W, Müller T, Welter F L, Federlein J, Heidbrink K, Przuntek H
Department of Neurology, Ruhr-University Bochum, St. Josef-Hospital, Federal Republic of Germany.
J Neural Transm (Vienna). 1996;103(10):1195-204. doi: 10.1007/BF01271204.
Recently distorted chromatic contour perception has been demonstrated in Parkinson's disease (PD). The aim of our study is to determine the clinical factors which influence chromatic contour perception in PD. Chromatic and achromatic contour perception, colour discrimination and clinical data were evaluated in 73 patients with PD. We used a computer-aided method to determine the chromatic fusion time (CFT) which indicates the acuity of monochromatic contour perception. Chromatic CFT was generally shortened in patients as compared to controls (p < 0.01), whereas achromatic CFT was not significantly different. Variance analysis revealed the ability of colour discrimination and the risk of visual hallucinations as statistically significant (p < 0.05) variables influencing contour perception of certain stimuli. In contrast, disease stage, disease duration and disease severity have no relevant effect on chromatic contour perception in Parkinson's disease. On the basis of those properties one may suggest that distorted chromatic contour perception is due to an impairment at a central stage of visual processing in PD and an imbalance of the serotonergic system. Whether CFT is a reliable method to predict the individual risk of hallucinosis in PD has to be evaluated.
最近在帕金森病（PD）中已证实存在色轮廓感知失真。我们研究的目的是确定影响PD患者色轮廓感知的临床因素。对73例PD患者评估了色和非色轮廓感知、颜色辨别及临床数据。我们使用一种计算机辅助方法来确定色融合时间（CFT），它表明单色轮廓感知的敏锐度。与对照组相比，患者的色CFT普遍缩短（p < 0.01），而非色CFT无显著差异。方差分析显示颜色辨别能力和视幻觉风险是影响某些刺激轮廓感知的具有统计学意义（p < 0.05）的变量。相比之下，疾病分期、病程和疾病严重程度对帕金森病的色轮廓感知无相关影响。基于这些特性，有人可能会认为色轮廓感知失真归因于PD视觉处理中枢阶段的损伤以及血清素能系统的失衡。CFT是否是预测PD患者幻觉症个体风险的可靠方法还有待评估。
