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The lectin pathway of the complement system.

作者信息

Matsushita M

机构信息

Department of Biochemistry, Fukushima Medical College, Japan.

出版信息

Microbiol Immunol. 1996;40(12):887-93. doi: 10.1111/j.1348-0421.1996.tb01156.x.

DOI:10.1111/j.1348-0421.1996.tb01156.x
PMID:9013485
Abstract
摘要

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The lectin pathway of the complement system.
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Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2.重组人甘露聚糖结合凝集素(MBL)与重组MBL相关丝氨酸蛋白酶-2揭示的MBL和C1复合物自激活的不同途径
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MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway.MASP-2,即甘露聚糖结合凝集素补体激活途径中产生C3转化酶的蛋白酶。
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Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene.补体甘露聚糖结合凝集素激活途径起始复合物的两种成分由单个结构基因编码。
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Evidence of lectin complement pathway activation in poststreptococcal glomerulonephritis.链球菌感染后肾小球肾炎中凝集素补体途径激活的证据。
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Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.凝集素途径效应酶甘露聚糖结合凝集素相关丝氨酸蛋白酶-2在缺乏C4和/或C2的情况下可激活天然补体C3。
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