Ben-Ze'ev A
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Curr Opin Cell Biol. 1997 Feb;9(1):99-108. doi: 10.1016/s0955-0674(97)80158-5.
In the past year, significant progress has been made in the attempt to understand the molecular mechanisms underlying signaling that is induced by cell-cell and cell-extracellular-matrix adhesion and that involves the cytoskeleton. In particular, molecules of the cytoplasmic plaques of cell-cell junctions have been shown to complex with transcription factors and to translocate into the nucleus. In addition, such junctional plaque proteins have been shown to act as effective suppressors of tumorigenesis.
在过去的一年里，在试图理解由细胞间和细胞与细胞外基质粘附所诱导且涉及细胞骨架的信号传导的分子机制方面取得了重大进展。特别是，已表明细胞间连接的细胞质斑块分子可与转录因子形成复合物并转运至细胞核。此外，这种连接斑块蛋白已被证明是有效的肿瘤发生抑制因子。
