信使核糖核酸与细胞骨架丝。
mRNA and cytoskeletal filaments.
作者信息
Bassell G, Singer R H
机构信息
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
出版信息
Curr Opin Cell Biol. 1997 Feb;9(1):109-15. doi: 10.1016/s0955-0674(97)80159-7.
The localization of some mRNAs to distinct intracellular regions is achieved through interactions of the mRNA with cytoskeletal filaments. RNA-cytoskeletal interactions exist that influence the transport, anchoring and translation of mRNA. Recent analysis of RNA movements in living cells suggests the formation of RNA granules and their active transport along microtubules. The anchoring and translation of mRNA may be mediated by interactions with orthogonal networks of F-actin and elongation factor 1alpha.
一些mRNA定位于不同的细胞内区域是通过mRNA与细胞骨架细丝的相互作用实现的。存在影响mRNA运输、锚定和翻译的RNA-细胞骨架相互作用。最近对活细胞中RNA运动的分析表明形成了RNA颗粒并沿微管进行主动运输。mRNA的锚定和翻译可能由与F-肌动蛋白和延伸因子1α的正交网络的相互作用介导。
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