Graduate Program in Neuroscience, Weill Cornell Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA.
Open Biol. 2012 Jun;2(6):120079. doi: 10.1098/rsob.120079.
Much of our knowledge on the roles of intra-axonal translation derives from the characterization of a small number of individual mRNAs that were found to be localized in axons. However, two recent studies, using large-scale approaches to provide a more comprehensive characterization of the axonal transcriptome, have led to the discovery of thousands of axonal mRNAs. The apparent abundance of mRNAs in axons raises the possibility that local translation has many more functions than previously thought. Here, we review the recent studies that have profiled axonal mRNAs and discuss how the identification of axonal transcripts might point to unappreciated roles for local translation in axons.
我们对轴内翻译作用的了解大多来自于少数被发现定位于轴突的个别 mRNA 的特征描述。然而，最近的两项研究使用大规模方法对轴突转录组进行更全面的特征描述，从而发现了数千种轴突 mRNA。mRNA 在轴突中明显丰富，这使得局部翻译的功能可能比之前认为的更多。在这里，我们回顾了最近对轴突 mRNA 进行分析的研究，并讨论了鉴定轴突转录本如何可能指出局部翻译在轴突中未被重视的作用。
