Modolell M, Eichmann K, Soler G
Max-Planck-Institut für Immunbiologie, Freiburg, Germany.
FEBS Lett. 1997 Jan 20;401(2-3):123-6. doi: 10.1016/s0014-5793(96)01451-2.
N(G)-Hydroxy-L-arginine is an intermediate metabolite in the synthesis of nitric oxide that is upregulated and secreted during acute inflammation in vivo. Previous reports have shown that chemically induced superoxide anion oxidizes N(G)-hydroxy-L-arginine to nitric oxide. Here, we demonstrate that this reaction takes place physiologically in phagocytic cells during the respiratory burst, and is independent of the presence of nitric oxide synthase.
N（G）-羟基-L-精氨酸是一氧化氮合成过程中的一种中间代谢产物，在体内急性炎症期间会上调并分泌。先前的报告表明，化学诱导的超氧阴离子会将N（G）-羟基-L-精氨酸氧化为一氧化氮。在这里，我们证明该反应在吞噬细胞呼吸爆发期间在生理条件下发生，并且与一氧化氮合酶的存在无关。
