Donnerer J
Department of Experimental and Clinical Pharmacology, University of Graz, Austria.
Neurosci Lett. 1996 Dec 27;221(1):33-6. doi: 10.1016/s0304-3940(96)13281-x.
Intraplantar injections of nerve growth factor (NGF; five injections of 4 micrograms each in 30 h intervals) were able to locally improve the recovery of the noradrenaline content in 6-hydroxydopamine (6-OHDA)-lesioned sympathetic nerves in adult rats. Whereas 8 days after the 6-OHDA treatment the noradrenaline content in the paw skin was still less than 10% of control, it reached up to 40% of control levels in NGF injected paws. Intraplantar NGF also significantly improved the recovery of the noradrenaline content in the innervating sciatic nerve, but not in distant tissues. The NGF-induced recovery of noradrenergic nerves was independent of the presence of sensory peptidergic afferents and it could not be mimicked by a local inflammatory response known to raise endogenous NGF production. These results show that rather low doses of exogenous NGF were able to locally restore peripheral noradrenergic nerves after an acute neurotoxin lesion.
向成年大鼠足底注射神经生长因子（NGF；每隔30小时注射5次，每次4微克）能够局部改善6-羟基多巴胺（6-OHDA）损伤的交感神经中去甲肾上腺素含量的恢复情况。在6-OHDA处理8天后，爪部皮肤中的去甲肾上腺素含量仍不到对照组的10%，而在注射NGF的爪部，该含量达到了对照组水平的40%。足底注射NGF也显著改善了支配坐骨神经中去甲肾上腺素含量的恢复，但对远处组织没有作用。NGF诱导的去甲肾上腺素能神经的恢复与感觉肽能传入神经的存在无关，并且已知能提高内源性NGF产生的局部炎症反应无法模拟这种恢复。这些结果表明，相当低剂量的外源性NGF能够在急性神经毒素损伤后局部恢复外周去甲肾上腺素能神经。
