Aotsuka A, Shinotoh H, Hattori T
Department of Neurology, School of Medicine, Chiba University.
Nihon Rinsho. 1997 Jan;55(1):249-54.
Recent advances in magnetic resonance spectroscopy(MRS) allow to assay noninvasively key molecules of brain metabolism in living patients. There are several reports of MRS in Parkinson's disease(PD) and multiple system atrophy(MSA). 1H-MRS of the striatum revealed the reduced NAA/Cr and Cho/Cr ratio in MSA patients and the preserved NAA/Cr and Cho/Cr ratio in PD patients. The reduced NAA/Cr ratio probably reflects striatal neuronal loss. 1H-MRS of the striatum showed increased Cho/Cr ratio in the "on" state compared with that in the "off" state in the PD patients. The increased Cho/Cr ratio may reflect some membrane alteration or change of choline metabolism in PD with the "wearing-off" phenomena. Although studies are still preliminary, MRS shows great possibility for aiding in the differential diagnosis of parkinsonism and it will contribute to a better understanding of the pathogenesis of PD and MSA.
磁共振波谱（MRS）的最新进展使得在活体患者中对脑代谢的关键分子进行无创检测成为可能。有几篇关于帕金森病（PD）和多系统萎缩（MSA）的MRS报告。纹状体的1H-MRS显示，MSA患者的NAA/Cr和Cho/Cr比值降低，而PD患者的NAA/Cr和Cho/Cr比值保持不变。NAA/Cr比值降低可能反映了纹状体神经元的丢失。PD患者纹状体的1H-MRS显示，与“关”状态相比，“开”状态下的Cho/Cr比值增加。Cho/Cr比值增加可能反映了PD患者出现“剂末现象”时的一些膜改变或胆碱代谢变化。尽管研究仍处于初步阶段，但MRS在辅助帕金森综合征的鉴别诊断方面显示出巨大潜力，并且将有助于更好地理解PD和MSA的发病机制。
