Suresh R, Devi P U, Baskar R
Department of Anatomy, Kasturba Medical College, Manipal, India.
Indian J Exp Biol. 1996 Sep;34(9):895-7.
Pregnant Swiss albino mice were exposed to diagnostic ultrasound (3.5 MHz, 65mw, ISPTP = 1 W/cm2, ISATA = 240 W/cm2) for 10 min on day 14, 16 or 17 of gestation to assess any changes in physiological reflexes (pinna detachment, eye opening and fur development) and postnatal mortality. Changes in locomotor activity by open field test and dark/bright arena test and learning and memory by hole board test were also recorded. No change was observed in physiological reflexes and postnatal mortality. However there were significant alterations in behavior in all the three exposed groups. These results demonstrate that ultrasound exposure during the late fetal period can impair brain function in adult mouse.
怀孕的瑞士白化小鼠在妊娠第14、16或17天接受诊断性超声（3.5兆赫，65毫瓦，ISPTP = 1瓦/平方厘米，ISATA = 240瓦/平方厘米）照射10分钟，以评估生理反射（耳廓分离、睁眼和毛发发育）及产后死亡率的任何变化。还记录了通过旷场试验和明暗场试验测定的运动活动变化，以及通过洞板试验测定的学习和记忆变化。未观察到生理反射和产后死亡率有变化。然而，所有三个暴露组的行为均有显著改变。这些结果表明，胎儿后期暴露于超声可损害成年小鼠的脑功能。
