Jorgensen L N, Kallehave F, Karlsmark T, Gottrup F
Department of Urology, Hvidovre Hospital, Denmark.
Br J Surg. 1996 Nov;83(11):1591-4. doi: 10.1002/bjs.1800831133.
The preoperative and postoperative wound-healing capacity of 23 patients undergoing elective major abdominal, thoracic or urological surgery was tested objectively by the subcutaneous accumulation of hydroxyproline and proline in an expanded polytetrafluoroethylene (ePTFE) tube. Before scheduled surgery two ePTFE tubes were implanted for removal after 5 and 10 days. This was repeated for each patient immediately after surgery. After 10 days a higher amount of hydroxyproline was measured before than after operation (median 2.91 (range 0.37-14.45) versus 1.45 (range 0.26-6.94) micrograms/cm, P = 0.01)). This decline was significantly higher in the six patients who had a postoperative infection (median 3.02 (range -0.06 to 6.14) versus 0.36 (range -1.56 to 12.60) micrograms/cm, P = 0.02). This study shows that major surgery is associated with impairment of subcutaneous collagen accumulation in a test wound, suggesting diminished systemic wound-healing capacity in such patients.
通过在扩张聚四氟乙烯（ePTFE）管中皮下积累羟脯氨酸和脯氨酸，对23例行择期腹部、胸部或泌尿外科大手术患者的术前和术后伤口愈合能力进行了客观测试。在预定手术前，植入两根ePTFE管，分别于5天和10天后取出。每位患者术后立即重复此操作。10天后，术前测得的羟脯氨酸量高于术后（中位数2.91（范围0.37 - 14.45）对1.45（范围0.26 - 6.94）微克/厘米，P = 0.01）。在6例术后感染患者中，这种下降明显更高（中位数3.02（范围 - 0.06至6.14）对0.36（范围 - 1.56至12.60）微克/厘米，P = 0.02）。本研究表明，大手术与测试伤口皮下胶原蛋白积累受损有关，提示此类患者全身伤口愈合能力下降。
