• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured L cells by the hypocholesterolemic drug clofibrate.

作者信息

Kaneko I, Hazama-Shimada Y, Kuroda M, Endo A

出版信息

Biochem Biophys Res Commun. 1977 Jun 20;76(4):1207-13. doi: 10.1016/0006-291x(77)90984-6.

DOI:10.1016/0006-291x(77)90984-6
PMID:901472
Abstract
摘要

相似文献

1
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured L cells by the hypocholesterolemic drug clofibrate.降胆固醇药物氯贝丁酯对培养的L细胞中3-羟基-3-甲基戊二酰辅酶A还原酶的抑制作用。
Biochem Biophys Res Commun. 1977 Jun 20;76(4):1207-13. doi: 10.1016/0006-291x(77)90984-6.
2
Hypocholesterolemic agents V: Inhibition of beta-hydroxy-beta-methylglutaryl coenzyme A reductase by substituted 4-biphenylylalkyl carboxylic acids and methyl esters.
J Pharm Sci. 1976 Sep;65(9):1374-80. doi: 10.1002/jps.2600650928.
3
Hypocholesterolemic agents III: inhibition of beta-hydroxy-beta-methylglutaryl coenzyme A reductase by half acid esters of 1-(4-biphenylyl)pentanol.
J Pharm Sci. 1976 Apr;65(4):548-52. doi: 10.1002/jps.2600650417.
4
Hypocholesterolemic agents IV: inhibition of beta-hydroxy-beta-methyglutaryl coenzyme A reductase by arylalkenyl and arylepoxy hydrogen succinates and glutarates.
J Pharm Sci. 1976 May;65(5):724-7. doi: 10.1002/jps.2600650523.
5
Lack of effect of clofibrate on hepatic HMG-CoA reductase activity in young swine in the postabsorptive state.氯贝丁酯对处于吸收后状态的幼猪肝脏HMG-CoA还原酶活性无影响。
Exp Mol Pathol. 1976 Dec;25(3):301-10. doi: 10.1016/0014-4800(76)90040-x.
6
Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor.普伐他汀钠（一种3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂）对体内胆固醇合成的组织选择性抑制作用。
Biochim Biophys Acta. 1990 Jul 16;1045(2):115-20. doi: 10.1016/0005-2760(90)90139-o.
7
Hypocholesterolemic agents VII: Inhibition of beta-hydroxy-beta-methylglutaryl-CoA reductase by monoesters of substituted glutaric acids.
J Pharm Sci. 1980 May;69(5):506-9. doi: 10.1002/jps.2600690507.
8
Cholesterol, 7-ketocholesterol and 25-hydroxycholesterol uptake studies and effect on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in human fibroblasts.胆固醇、7-酮胆固醇和25-羟基胆固醇摄取研究及其对人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的影响。
Biochim Biophys Acta. 1975 Jul 22;398(1):10-7. doi: 10.1016/0005-2760(75)90165-4.
9
Time-dependent, irreversible inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by the antibiotic citrinin.抗生素桔霉素对3-羟基-3-甲基戊二酰辅酶A还原酶的时间依赖性不可逆抑制作用。
Biochim Biophys Acta. 1977 Jul 20;488(1):97-101.
10
Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor.氧化甾醇在调节3-羟基-3-甲基戊二酰辅酶A还原酶降解、抑制3-羟基-3-甲基戊二酰辅酶A合酶以及与氧化甾醇受体亲和力方面的效力之间的相关性。
Biochem Biophys Res Commun. 1992 Jul 15;186(1):182-9. doi: 10.1016/s0006-291x(05)80791-0.

引用本文的文献

1
Antiviral activity of antilipidemic compounds on herpes simplex virus type 1.抗血脂化合物对1型单纯疱疹病毒的抗病毒活性。
Antimicrob Agents Chemother. 1980 Aug;18(2):269-75. doi: 10.1128/AAC.18.2.269.
2
Bezafibrate fails to directly modulate HMG-CoA reductase or LDL catabolism in human mononuclear cells.苯扎贝特不能直接调节人单核细胞中的HMG-CoA还原酶或低密度脂蛋白分解代谢。
Eur J Clin Pharmacol. 1991;40 Suppl 1:S37-40.