扩张和进食对人近端胃张力阶段性变化的影响。
Effect of distension and feeding on phasic changes in human proximal gastric tone.
作者信息
Ahluwalia N K, Thompson D G, Barlow J
机构信息
Department of Medicine (Section of Gastroenterology), University of Manchester Medical School, Hope Hospital.
出版信息
Gut. 1996 Nov;39(5):757-61. doi: 10.1136/gut.39.5.757.
BACKGROUND
Proximal stomach by virtue of its property of accommodation acts as a reservoir for the ingested food, but its role in emptying and the factors modulating it remain unexplored.
AIM
To assess the effects of distension and of feeding on proximal gastric tone.
SUBJECTS
14 healthy volunteers with no current or past history of any gastro-intestinal symptoms.
METHODS
Isobaric changes in volume of the proximal stomach were recorded both during fasting and for the first 30 minutes after a meal.
RESULTS
For a given degree of distension, the mean (SEM) intragastric pressure was consistently lower, immediately after meal ingestion (9.8 (1.1), mm Hg) than during fasting (12.9 (0.6) mm Hg; p < 0.01). Proximal gastric tone was continuously variable with a frequency of fluctuation of 0.9-1.3/minute and an amplitude of 16.8 (2.2) ml, superimposed upon slower higher amplitude fluctuations in baseline tone. These variations in tone were unaffected by the degree of gastric distension or by food.
CONCLUSIONS
While proximal gastric tone decreases after meal ingestions consistent with accommodation, the fluctuations in tone are not an importance factor in the modulation of nutrient emptying from the proximal stomach in the immediate postprandial period.
背景
近端胃凭借其容纳特性，作为摄入食物的储存库，但其在排空方面的作用以及调节排空的因素仍未得到探索。
目的
评估扩张和进食对近端胃张力的影响。
研究对象
14名无当前或既往任何胃肠道症状病史的健康志愿者。
方法
在空腹期间以及进食后最初30分钟内记录近端胃容积的等压变化。
结果
对于给定程度的扩张，进食后即刻的平均（标准误）胃内压（9.8（1.1）毫米汞柱）始终低于空腹时（12.9（0.6）毫米汞柱；p<0.01）。近端胃张力持续变化，波动频率为0.9 - 1.3次/分钟，幅度为16.8（2.2）毫升，叠加在基线张力较慢的高幅度波动之上。这些张力变化不受胃扩张程度或食物的影响。
结论
虽然进食后近端胃张力降低与容纳作用一致，但在餐后即刻，张力波动并非调节近端胃营养物质排空的重要因素。
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