Nazar K, Kaciuba-Uscilko H, Ziemba W, Krysztofiak H, Wójcik-Ziólkowska E, Niewiadomski W, Chwalbinska-Moneta J, Bicz B, Stupnicka E, Okinczyc A
Department of Applied Physiology, Polish Academy of Sciences, Warsaw, Poland.
Clin Physiol. 1997 Jan;17(1):1-18. doi: 10.1046/j.1365-2281.1997.01818.x.
Exaggerated blood pressure (BP) response to exercise in normotensive subjects is considered as a predictor of future hypertension. The aim of the study was to find out whether elevated BP response to exercise is associated with any other haemodynamic, metabolic or hormonal abnormalities. Abnormal BP response to exercise, i.e. systolic BP (SBP) > 200 mmHg at 150 W or lower workload, was found in 37 out of 180 normotensive, male students, aged 20-24 years. Fifteen students with elevated exercise BP (group E) volunteered for further examinations. Their resting and ambulatory BP showed high normal values. Eight of them had a family history of hypertension. Four subjects met the criteria of cardiac hypertrophy. Significant correlations were found between exercise SBP and left ventricular mass index, average 24 h and daytime SBP recordings. In comparison with normal subjects of the same age (group N, n = 13), those from group E did not differ in body mass index, plasma lipid profile, fasting glucose, insulin and catecholamine (CA) concentrations, but had increased erythrocyte sodium content, slightly elevated plasma renin activity and cortisol level. During exercise, E subjects showed greater cardiac output (CO) increases with normal heart rate, total peripheral resistance (TPR) and plasma CA. There were no significant differences between groups in haemodynamic and plasma CA responses to posture change from supine to standing. Glucose ingestion (75 g) caused smaller increases in CO and smaller decreases in TPR in E than in N subjects without differences in BP, blood glucose plasma insulin and CA. It is concluded that young normotensive men with exaggerated BP response to exercise show some other characteristics that may be considered as markers of predisposition to hypertension or factors promoting the development of hypertension.
血压正常的受试者运动时血压（BP）反应过度被认为是未来患高血压的一个预测指标。本研究的目的是探究运动时血压升高反应是否与任何其他血液动力学、代谢或激素异常有关。在180名年龄在20 - 24岁的血压正常的男性学生中，有37人被发现存在运动时血压异常反应，即在150瓦或更低工作量时收缩压（SBP）> 200 mmHg。15名运动血压升高的学生（E组）自愿接受进一步检查。他们的静息血压和动态血压显示为高正常水平。其中8人有高血压家族史。4名受试者符合心脏肥大的标准。运动收缩压与左心室质量指数、24小时平均收缩压和日间收缩压记录之间存在显著相关性。与同年龄的正常受试者（N组，n = 13）相比，E组受试者在体重指数、血脂谱、空腹血糖、胰岛素和儿茶酚胺（CA）浓度方面没有差异，但红细胞钠含量增加，血浆肾素活性和皮质醇水平略有升高。运动期间，E组受试者在心率、总外周阻力（TPR）和血浆CA正常的情况下心输出量（CO）增加更大。两组在从仰卧位到站立位姿势改变时的血液动力学和血浆CA反应方面没有显著差异。摄入葡萄糖（75克）后，E组受试者的心输出量增加较小，总外周阻力降低较小，而血压、血糖、血浆胰岛素和CA方面两组没有差异。结论是，运动时血压反应过度的年轻血压正常男性表现出一些其他特征，这些特征可能被视为易患高血压的标志物或促进高血压发展的因素。
