Zhivotovsky B, Burgess D H, Schlegel J, Pörn M I, Vanags D, Orrenius S
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
J Cell Biochem. 1997 Jan;64(1):43-9.
Involvement of a unique family of cysteine proteases in the multistep apoptotic process has been documented. Cloning of several mammalian genes identifies some components of this cellular response. However, it is currently unclear which protease plays a role as a signal and/or effector of apoptosis. We summarize contributions to the data concerning proteases in Fas-mediated apoptosis.
已经证明，一类独特的半胱氨酸蛋白酶参与了多步骤凋亡过程。几个哺乳动物基因的克隆确定了这种细胞反应的一些组成部分。然而，目前尚不清楚哪种蛋白酶作为凋亡的信号和/或效应器发挥作用。我们总结了关于蛋白酶在Fas介导的凋亡中所起作用的数据。
