Shapira Y, Gurevich B, Artru A A, Lam A M, Israel E, Zachari S, Gurman G, Feldman Z
Division of Anesthesiology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva Israel.
J Neurosurg Anesthesiol. 1997 Jan;9(1):51-7. doi: 10.1097/00008506-199701000-00012.
We designed the present study to determine whether the minimum alveolar concentration (MAC) for isoflurane is decreased after closed head trauma (CHT) in rats and, if so, whether the decrease of MAC is related to the severity of neurological impairment following CHT. Isoflurane MAC was determined in 36 Sprague-Dawley rats. Then, at time = 0 h, animals were grouped. Group 1 (n = 8) received no CHT, group 2 (n = 14) received moderate CHT, and group 3 (n = 14) received severe CHT. Neurological severity score (NSS, 0 = no deficit and 25 = maximal impairment) and MAC were determined at 1, 4, 24, and 48 h. In groups 1 and 2, isoflurane MAC at 1, 2, 24, and 48 h (1.0-1.1 +/- 0.8-1.2%, median +/- range) was not significantly different from baseline (1.0-1.1 +/- 1.0-1.1%). In group 3, isoflurane MAC at 1, 2, 24, and 48 h (0.4 +/- 0.2-0.5%) was decreased as compared to baseline (1.1 +/- 1.0-1.1%). In group 2, NSS at 1 h was 18 +/- 11-21 and improved by 48 h to 9 +/- 4-15. In group 3, NSS at 1 h was 24 +/- 22-25 and was not significantly different from NSS at 48 h (24 +/- 24-25). Thus, moderate CHT does not significantly alter isoflurane MAC, whereas severe CHT equivalent to a Glasgow Coma Scale score of 3 to 6 significantly decreases isoflurane MAC.
我们开展本研究以确定大鼠闭合性颅脑损伤（CHT）后异氟烷的最低肺泡浓度（MAC）是否降低，若降低，MAC的降低是否与CHT后神经功能损害的严重程度相关。测定了36只Sprague-Dawley大鼠的异氟烷MAC。然后，在时间=0小时时，将动物分组。第1组（n = 8）未接受CHT，第2组（n = 14）接受中度CHT，第3组（n = 14）接受重度CHT。在1、4、24和48小时测定神经严重程度评分（NSS，0 =无缺陷，25 =最大损伤）和MAC。在第1组和第2组中，1、2、24和48小时的异氟烷MAC（1.0 - 1.1 +/- 0.8 - 1.2%，中位数 +/- 范围）与基线（(1.0 - 1.1 +/- 1.0 - 1.1%）无显著差异。在第3组中，1、2、24和48小时的异氟烷MAC（0.4 +/- 0.2 - 0. .5%）与基线（1.1 +/- 1.0 - 1.1%）相比降低。在第2组中，1小时时的NSS为18 +/- 11 - 21，到48小时时改善至9 +/- 4 - 15。在第3组中，1小时时的NSS为24 +/- 22 - 25，与48小时时的NSS（24 +/- 24 - 25）无显著差异。因此，中度CHT不会显著改变异氟烷MAC，而相当于格拉斯哥昏迷量表评分为3至6分的重度CHT会显著降低异氟烷MAC。
