SCOP：蛋白质数据库的结构分类
SCOP: a structural classification of proteins database.
作者信息
Hubbard T J, Murzin A G, Brenner S E, Chothia C
机构信息
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.
出版信息
Nucleic Acids Res. 1997 Jan 1;25(1):236-9. doi: 10.1093/nar/25.1.236.
Abstract
The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of all known proteins structures. The classification is on hierarchical levels: the first two levels, family and superfamily, describe near and far evolutionary relationships; the third, fold, describes geometrical relationships. The distinction between evolutionary relationships and those that arise from the physics and chemistry of proteins is a feature that is unique to this database, so far. SCOP also provides for each structure links to atomic co-ordinates, images of the structures, interactive viewers, sequence data, data on any conformational changes related to function and literature references. The database is freely accessible on the World Wide Web (WWW) with an entry point at URL http://scop.mrc-lmb.cam.ac.uk/scop/
摘要
蛋白质结构分类（SCOP）数据库对所有已知蛋白质结构之间的关系进行了详细而全面的描述。该分类具有层次级别：前两个级别，即家族和超家族，描述了近缘和远缘进化关系；第三个级别，即折叠，描述了几何关系。进化关系与源于蛋白质物理化学性质的关系之间的区别是该数据库目前独有的一个特征。SCOP还为每个结构提供了指向原子坐标、结构图像、交互式查看器、序列数据、与功能相关的任何构象变化数据以及文献参考的链接。该数据库可通过万维网（WWW）免费访问，入口网址为http://scop.mrc-lmb.cam.ac.uk/scop/
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