Skarin A, Florén I, Kiss K, Miörner H, Stenevi U
Department of Ophthalmology, University Hospital of Lund, Sweden.
Acta Ophthalmol Scand. 1996 Dec;74(6):593-7. doi: 10.1111/j.1600-0420.1996.tb00742.x.
Eight patients with Acanthamoeba keratitis were diagnosed and treated at our clinic between February 1991 and February 1993. Five of these were contact lens wearers, two had suffered recent corneal trauma and one had recently undergone penetrating keratoplasty. The diagnoses were based on both culture and histological examination of biopsy material in three cases, on culture alone in two cases and on histological examination alone in three cases. In all but one primary treatment was Propamidine isethionate and Neomycin/Polymyxin B topically and Ketoconazole orally. Because of poor healing three patients additionally received Paromomycin and Miconazole or Clotrimazol topically; two of these were further treated with Polyhexamethylene biguanide topically. The interval from initial symptoms to accurate diagnoses varied from one to eleven months. In one patient the eye could not be saved; in the remaining patients visual acuity after healing ranged from hand movements to 1.0.
1991年2月至1993年2月期间，我们诊所诊断并治疗了8例棘阿米巴角膜炎患者。其中5例为隐形眼镜佩戴者，2例近期有角膜外伤史，1例近期接受了穿透性角膜移植术。3例诊断基于活检材料的培养和组织学检查，2例仅基于培养，3例仅基于组织学检查。除1例患者外，所有患者的初始治疗均为局部使用依西酸丙氧苯脒和新霉素/多粘菌素B，口服酮康唑。由于愈合不佳，3例患者额外局部使用了巴龙霉素和咪康唑或克霉唑；其中2例进一步局部使用了聚六亚甲基双胍。从初始症状到准确诊断的间隔时间为1至11个月。1例患者的眼睛未能保住；其余患者愈合后的视力范围从手动视力到1.0。
