Wiedłocha A
Department of Biochemistry, Norwegian Radium Hospital, Montebello, Oslo, Norway.
Arch Immunol Ther Exp (Warsz). 1996;44(4):201-7.
The plasma membrane represents an impermeable barrier to proteins and other macromolecules. However, certain exogenous proteins are able to cross cellular membranes and gain access to the cytosol. The best examples are bacterial and plant protein toxins, acting on intracellular targets. During last few years the number of known proteins possessing the capability to cross cellular membranes in the reverse direction and reach the nucleus has increased (acidic and basic fibroblast growth factor, interleukin 1, angiogenin, Schwannoma derived growth factor, homeoprotein Antennapedia, HIV-1 Tat protein are some examples). Here, the role of transport of exogenous acidic fibroblast growth factor to the nuclear location as a part of the growth factor signaling is discussed, and the current knowledge on this issue is reviewed.
质膜对蛋白质和其他大分子来说是一道不可渗透的屏障。然而，某些外源蛋白质能够穿过细胞膜并进入细胞质溶胶。最好的例子是作用于细胞内靶点的细菌和植物蛋白毒素。在过去几年中，已知具有反向穿过细胞膜并到达细胞核能力的蛋白质数量有所增加（酸性和碱性成纤维细胞生长因子、白细胞介素1、血管生成素、雪旺瘤衍生生长因子、同源异型蛋白触角足蛋白、HIV-1 Tat蛋白等都是例子）。在此，讨论了外源酸性成纤维细胞生长因子向核定位转运作为生长因子信号传导一部分的作用，并综述了关于这个问题的现有知识。
