Góra-Tybor J, Krykowski E, Robak T
Department of Hematology, Medical Academy, Lóź, Poland.
Arch Immunol Ther Exp (Warsz). 1996;44(4):255-8.
The application of granulocyte-macrophage and granulocyte colony stimulation factors (GM-CSF and G-CSF) has been progressively increased in the treatment of patients with agranulocytosis. The aim of our study was to compare the time of neutrophil recovery in patients with severe agranulocytosis treated with G-CSF or GM-CSF and the historical control group. We have studied 6 patients with agranulocytosis treated with stimulating factors and 7 patients in historical control group. Most of the patients have been exposed to thiamazole or non-steroid antiinflammatory drugs. Our results demonstrate that patients receiving colony stimulating factor have a significantly shorter period of recovery (the mean time 8.7 +/- 1.98 days) than the historical control group (the mean time 11.0 +/- 2.24 days). We observed also a shorter time of antibiotico-therapy and hospitalization in the group of patients treated with colony stimulating factor.
粒细胞巨噬细胞集落刺激因子和粒细胞集落刺激因子（GM-CSF和G-CSF）在粒细胞缺乏症患者治疗中的应用已逐渐增加。我们研究的目的是比较接受G-CSF或GM-CSF治疗的严重粒细胞缺乏症患者与历史对照组中性粒细胞恢复的时间。我们研究了6例接受刺激因子治疗的粒细胞缺乏症患者和7例历史对照组患者。大多数患者接触过甲巯咪唑或非甾体类抗炎药。我们的结果表明，接受集落刺激因子治疗的患者恢复时间明显短于历史对照组（平均时间8.7±1.98天对比平均时间11.0±2.24天）。我们还观察到接受集落刺激因子治疗的患者组抗生素治疗时间和住院时间较短。
