Pollack A E, Fink J S
Molecular Neurobiology Laboratory, Massachusetts General Hospital, Boston, USA.
Brain Res. 1996 Dec 16;743(1-2):124-30. doi: 10.1016/s0006-8993(96)01036-0.
The interaction between adenosine and D1 dopamine systems in regulating motor behavior and striatal c-Fos expression was examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions. These results were compared to the synergistic interaction between D1 and D2 dopamine systems in 6-OHDA rats. Coadministration of the adenosine antagonist 3,7-dimethyl-1-propargylxanthine (DMPX: 10 mg/kg) and the D1 dopamine agonist SKF38393 (0.5 mg/kg) to 6-OHDA-lesioned rats produced significant contralateral rotation and c-Fos expression in the ipsilateral striatum compared to 6-OHDA rats treated with either drug alone. However, the regional pattern of striatal c-Fos activation following treatment of 6-OHDA rats with SKF38393 and DMPX was different from the dorsolateral pattern of striatal c-Fos induction observed after coadministration of D1 and D2 dopamine agonists (SKF38393: 0.5 mg/kg + quinpirole: 0.05 mg/kg). These data are consistent with a functional interaction between D1 dopamine and adenosine systems in the striatum, but suggest that activation of different subsets of striatal neurons underlie the behavioral synergy observed following combined adenosine antagonist-D1 dopamine agonist and combined D1 dopamine agonist-D2 dopamine agonist treatment.
在单侧6-羟基多巴胺（6-OHDA）损伤的大鼠中，研究了腺苷与D1多巴胺系统在调节运动行为和纹状体c-Fos表达方面的相互作用。将这些结果与6-OHDA大鼠中D1和D2多巴胺系统之间的协同相互作用进行比较。与单独使用任一药物治疗的6-OHDA大鼠相比，向6-OHDA损伤的大鼠联合给予腺苷拮抗剂3,7-二甲基-1-丙炔基黄嘌呤（DMPX：10mg/kg）和D1多巴胺激动剂SKF38393（0.5mg/kg），可在同侧纹状体中产生显著的对侧旋转和c-Fos表达。然而，用SKF38393和DMPX治疗6-OHDA大鼠后，纹状体c-Fos激活的区域模式与联合给予D1和D2多巴胺激动剂（SKF38393：0.5mg/kg + 喹吡罗：0.05mg/kg）后观察到的纹状体c-Fos诱导的背外侧模式不同。这些数据与纹状体中D1多巴胺和腺苷系统之间的功能相互作用一致，但表明不同亚组的纹状体神经元激活是联合腺苷拮抗剂-D1多巴胺激动剂和联合D1多巴胺激动剂-D2多巴胺激动剂治疗后观察到的行为协同作用的基础。
