Kuroki T, Ichikawa J, Dai J, Meltzer H Y
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106-5000, USA.
Brain Res. 1996 Dec 16;743(1-2):357-61. doi: 10.1016/s0006-8993(96)01111-0.
Pretreatment with R(+)-8-OH-DPAT, a selective serotonin (5-HT)1A receptor agonist (50 micrograms/kg, s.c.), inhibited D-amphetamine sulfate (1.0 mg/kg, s.c.)-induced increases in extracellular levels of both 5-HT and dopamine (DA) in rat medial prefrontal cortex, as determined by in vivo microdialysis. The inhibitory effect of R(+)-8-OH-DPAT was completely reversed by the selective 5-HT1A receptor antagonist WAY 100,635 (100 micrograms/kg s.c.) administered 5 min prior to R(+)-8-OH-DPAT. These results suggest that stimulation of 5-HT1A receptors may inhibit amphetamine-induced release of 5-HT and DA in the medial prefrontal cortex.
采用体内微透析法测定发现，选择性5-羟色胺（5-HT）1A受体激动剂R(+)-8-OH-DPAT（50微克/千克，皮下注射）预处理可抑制硫酸右苯丙胺（1.0毫克/千克，皮下注射）诱导的大鼠内侧前额叶皮质细胞外5-羟色胺和多巴胺（DA）水平升高。在注射R(+)-8-OH-DPAT前5分钟皮下注射选择性5-HT1A受体拮抗剂WAY 100,635（100微克/千克），可完全逆转R(+)-8-OH-DPAT的抑制作用。这些结果表明，刺激5-HT1A受体可能会抑制内侧前额叶皮质中苯丙胺诱导的5-羟色胺和多巴胺释放。
