全髋关节置换术中林可霉素的血浆、骨、髋关节囊、滑膜及引流液浓度。
Plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin during total hip replacement.
作者信息
Parsons R L, Beavis J P, Hossack G A, Paddock G M
出版信息
Br J Clin Pharmacol. 1977 Aug;4(4):433-7. doi: 10.1111/j.1365-2125.1977.tb00758.x.
Abstract
1 Lincomycin (600 mg) was given 6 h preoperatively by intramuscular injection, as an intravenous infusion over 30 min and for 72 h postoperatively in twelve patients having total hip replacement. 2 The plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin were almost always above the M.I.C. of lincomycin against penicillinase producing Staphylococcus aureus. 3 There was a good correlation between the estimated concentrations of lincomycin in bone by the grinding and agitation methods of analysis. 4 Two patients developed pseudomembranous colitis after parenteral lincomycin.
摘要
十二例行全髋关节置换术的患者，术前6小时肌肉注射林可霉素（600毫克），术中静脉输注30分钟，术后72小时持续静脉输注。
林可霉素在血浆、骨、髋关节囊、滑膜和引流液中的浓度几乎始终高于林可霉素对产青霉素酶金黄色葡萄球菌的最低抑菌浓度。
通过研磨和搅拌分析方法估算的骨中林可霉素浓度之间存在良好的相关性。
两名患者在接受胃肠外林可霉素治疗后发生了假膜性结肠炎。
相似文献
1
Plasma, bone, hip capsule, synovial and drain fluid concentrations of lincomycin during total hip replacement.全髋关节置换术中林可霉素的血浆、骨、髋关节囊、滑膜及引流液浓度。
Br J Clin Pharmacol. 1977 Aug;4(4):433-7. doi: 10.1111/j.1365-2125.1977.tb00758.x.
2
Plasma, bone, hip capsule and drain fluid concentrations of ampicillin and flucloxacillin during total hip replacement after intravenous bolus injection of magnapen.静脉推注美洛培南后全髋关节置换术中氨苄西林和氟氯西林的血浆、骨、髋关节囊及引流液浓度。
Br J Clin Pharmacol. 1978 Aug;6(2):135-43. doi: 10.1111/j.1365-2125.1978.tb00838.x.
3
Lincomycin bone concentrations during total hip replacement [proceedings].全髋关节置换术中林可霉素的骨浓度[会议论文集]
Br J Clin Pharmacol. 1975 Aug;2(4):371P-372P.
4
Cephalothin and cefamandole penetration into bone, synovial fluid, and wound drainage fluid.
J Bone Joint Surg Am. 1980 Sep;62(6):981-5.
5
Cephaloridine penetration into bone and synovial capsule of patients undergoing hip joint replacement.头孢噻啶在髋关节置换患者骨骼和滑膜囊中的渗透情况。
J Antimicrob Chemother. 1975;1(3 Suppl):41-6. doi: 10.1093/jac/1.suppl_3.41.
6
Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats.静脉注射和肌肉注射林可霉素后猫体内的药代动力学及骨组织浓度
J Vet Pharmacol Ther. 2012 Dec;35(6):534-40. doi: 10.1111/j.1365-2885.2011.01355.x. Epub 2011 Dec 2.
7
Penetration of lincomycin ('Lincocin') and clindamycin ('Dalacin C') into the synovial cavity in rheumatoid arthritis.林可霉素（“洁霉素”）和克林霉素（“氯洁霉素”）在类风湿性关节炎中向滑膜腔的渗透情况。
Curr Med Res Opin. 1972;1(2):108-15. doi: 10.1185/03007997209111153.
8
Penetration of daptomycin into bone and synovial fluid in joint replacement.达托霉素在关节置换中进入骨组织和滑液的情况。
Antimicrob Agents Chemother. 2014 Jul;58(7):3991-6. doi: 10.1128/AAC.02344-14. Epub 2014 May 5.
9
Antibiotics in human hematoma and wound fluid.
Clin Orthop Relat Res. 1975 May(108):138-44. doi: 10.1097/00003086-197505000-00021.
10
Cefazolin concentrations in bone and synovial fluid.
J Bone Joint Surg Am. 1978 Apr;60(3):359-62.
引用本文的文献
1
Plasma, bone, hip capsule and drain fluid concentrations of ampicillin and flucloxacillin during total hip replacement after intravenous bolus injection of magnapen.静脉推注美洛培南后全髋关节置换术中氨苄西林和氟氯西林的血浆、骨、髋关节囊及引流液浓度。
Br J Clin Pharmacol. 1978 Aug;6(2):135-43. doi: 10.1111/j.1365-2125.1978.tb00838.x.
2
Plasma concentration/time curve of erythromycin after a 12-hour intravenous infusion of erythromycin lactobionate in man.在人体中静脉输注乳糖酸红霉素12小时后红霉素的血浆浓度/时间曲线。
Postgrad Med J. 1978 Feb;54(628):68-71. doi: 10.1136/pgmj.54.628.68.
本文引用的文献
1
Lincomycin in the treatment of osteomyelitis.林可霉素治疗骨髓炎
Practitioner. 1967 Mar;198(185):390-5.
2
Postoperative infection in total prosthetic replacement arthroplasty of the hip-joint. With special reference to the bacterial content of the air of the operating room.髋关节全假体置换术后感染。特别提及手术室空气的细菌含量。
Br J Surg. 1969 Sep;56(9):641-9. doi: 10.1002/bjs.1800560902.
3
Penetration of lincomycin, penicillin, and tetracycline into serum and bone.林可霉素、青霉素和四环素在血清及骨骼中的渗透情况。
Proc Soc Exp Biol Med. 1969 Jan;130(1):89-91. doi: 10.3181/00379727-130-33494.
4
Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone.实验性骨髓炎。II. 治疗试验及骨中抗生素水平的测定
J Infect Dis. 1971 Dec;124(6):565-71. doi: 10.1093/infdis/124.6.565.
5
Total hip replacement in osteoarthrosis using the Charnley prosthesis.使用查恩利假体进行骨关节炎全髋关节置换术。
Br Med J. 1972 Jun 24;2(5816):752-5. doi: 10.1136/bmj.2.5816.752.
6
Total hip replacement in inflammatory hip disease using the Charnley prosthesis.使用Charnley假体治疗炎性髋关节疾病的全髋关节置换术。
Br Med J. 1972 Jun 24;2(5816):750-2. doi: 10.1136/bmj.2.5816.750.
7
In-vitro comparison of erythromycin, lincomycin, and clindamycin.红霉素、林可霉素和克林霉素的体外比较
Br Med J. 1970 Apr 11;2(5701):89-90. doi: 10.1136/bmj.2.5701.89.
8
Penetration of lincomycin ('Lincocin') and clindamycin ('Dalacin C') into the synovial cavity in rheumatoid arthritis.林可霉素（“洁霉素”）和克林霉素（“氯洁霉素”）在类风湿性关节炎中向滑膜腔的渗透情况。
Curr Med Res Opin. 1972;1(2):108-15. doi: 10.1185/03007997209111153.
9
Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clinimycin.
Am J Med Sci. 1968 Nov;256(5):279-92. doi: 10.1097/00000441-196811000-00002.
10
Lincomycin bone concentrations during total hip replacement [proceedings].全髋关节置换术中林可霉素的骨浓度[会议论文集]
Br J Clin Pharmacol. 1975 Aug;2(4):371P-372P.
Zotero 插件