Rosen C L, Ratliff A F, Wolfe R E, Branney S W, Roe E J, Pons P T
Department of Emergency Medicine, Massachusetts General Hospital, Boston 02114, USA.
J Emerg Med. 1997 Jan-Feb;15(1):13-7. doi: 10.1016/s0736-4679(96)00259-4.
Droperidol is used for sedating combative patients in the emergency department (ED). We performed a randomized, prospective, double-blind study to evaluate the efficacy of droperidol in the management of combative patients in the prehospital setting. Forty-six patients intravenously received the contents of 2-cc vials of saline or droperidol (5 mg). Paramedics used a 5-point scale to quantify agitation levels prior to and 5 and 10 min after administration of the vials. Twenty-three patients received droperidol and 23 received saline. At 5 min, patients in the droperidol group were significantly less agitated than were patients in the saline group. At 10 min, this difference was highly significant. Eleven patients in the saline group (48%) required more sedation after arrival in the ED versus 3 patients (13%) in the droperidol group. We conclude that droperidol is effective in sedating combative patients in the prehospital setting.
氟哌利多用于急诊科对有攻击性的患者进行镇静。我们进行了一项随机、前瞻性、双盲研究，以评估氟哌利多在院前环境中对有攻击性患者的治疗效果。46例患者静脉注射2毫升生理盐水或氟哌利多（5毫克）。护理人员在注射前以及注射后5分钟和10分钟使用5分制量表对激动程度进行量化。23例患者接受氟哌利多治疗，23例接受生理盐水治疗。5分钟时，氟哌利多组患者的激动程度明显低于生理盐水组患者。10分钟时，这种差异非常显著。生理盐水组11例患者（48%）在到达急诊科后需要更多镇静，而氟哌利多组为3例患者（13%）。我们得出结论，氟哌利多在院前环境中对有攻击性的患者进行镇静是有效的。
