Bach F H, Ferran C, Hechenleitner P, Mark W, Koyamada N, Miyatake T, Winkler H, Badrichani A, Candinas D, Hancock W W
Sandoz Center for Immunobiology, Department of Surgery, New England Deaconess Hospital, Boston, Massachusetts, USA.
Nat Med. 1997 Feb;3(2):196-204. doi: 10.1038/nm0297-196.
Organ xenografts under certain circumstances survive in the presence of anti-graft antibodies and complement, a situation referred to as "accommodation." We find that the endothelial cells (ECs) in hamster hearts that accommodate themselves in rats express genes, such as A20 and bcl-2, that in vitro protect ECs from apoptosis and prevent upregulation in those cells of proinflammatory genes such as cytokines, procoagulant and adhesion molecules. Hearts that are rejected do not express these genes. In addition, vessels of rejected hearts show florid transplant arteriosclerosis whereas those of accommodated hearts do not. Accommodated xenografts have an ongoing T helper cell type 2 (Th2) cytokine immune response, whereas the rejected grafts have a Th1 response. We propose a model for factors that contribute to the survival of xenografts and the avoidance of transplant arteriosclerosis.
在某些情况下，器官异种移植能够在存在抗移植抗体和补体的情况下存活，这种情况被称为“适应”。我们发现，在大鼠体内适应的仓鼠心脏中的内皮细胞（ECs）表达诸如A20和bcl-2等基因，这些基因在体外可保护内皮细胞免于凋亡，并防止这些细胞中细胞因子、促凝剂和黏附分子等促炎基因的上调。被排斥的心脏不表达这些基因。此外，被排斥心脏的血管显示出明显的移植动脉硬化，而适应心脏的血管则没有。适应的异种移植具有持续的2型辅助性T细胞（Th2）细胞因子免疫反应，而被排斥的移植则具有Th1反应。我们提出了一个有助于异种移植存活和避免移植动脉硬化的因素模型。
