Laudo Pardos C, Puigdevall Gallego V, del Río Mayor M J, Velasco Martín A
Departamento de Farmacología, E.U. de Fisioterapia de Soria. U. de Valladolid, Hospital General del Insalud, Soria.
An Med Interna. 1996 Nov;13(11):555-61.
The main indication of thyroid hormone preparations is the treatment of hypothyroidism, ideally the goal of therapy is to restore the serum thyrotropin (TSH) concentration to a normal value. The optimal doses used to be stable, but several conditions may alter their requirements (reduced intestinal absorption, pregnancy,...). Levothyroxine therapy is also used in the benign nodular disease and after surgery in patients with thyroid cancer. The overtreatment with thyroxine and the problems related to bone mineral density seems of special importance.
甲状腺激素制剂的主要适应证是治疗甲状腺功能减退症,理想的治疗目标是将血清促甲状腺激素(TSH)浓度恢复至正常水平。过去常用的最佳剂量较为稳定,但一些情况可能会改变所需剂量(肠道吸收减少、妊娠等)。左甲状腺素治疗也用于良性结节性疾病以及甲状腺癌患者术后。甲状腺素过度治疗以及与骨矿物质密度相关的问题似乎尤为重要。