Bowman L C, Riely C A
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Surg Oncol Clin N Am. 1996 Apr;5(2):451-9.
Historically, children with liver tumors were uniformly considered to have a poor prognosis and were approached warily by pediatric surgeons and oncologists. Over the last decade, however, advances in diagnostic imaging technology, discovery of effective chemotherapy, and improved surgical techniques have greatly facilitated the management of children with hepatic tumors. Although orthotopic liver transplantation has emerged as a viable treatment option in the management of hepatic malignancies, including hepatoblastoma and hepatocellular carcinoma, its use is still controversial.
从历史上看，患有肝脏肿瘤的儿童一直被普遍认为预后不佳，儿科外科医生和肿瘤学家对其治疗都持谨慎态度。然而，在过去十年中，诊断成像技术的进步、有效化疗方法的发现以及手术技术的改进，极大地推动了儿童肝脏肿瘤的治疗。尽管原位肝移植已成为治疗肝脏恶性肿瘤（包括肝母细胞瘤和肝细胞癌）的一种可行选择，但其应用仍存在争议。
