Hoerauf K, Hosemann W, Wild K, Hobbhahn J
Klinik für Anästhesiologie, Klinikum der Universität Regensburg.
HNO. 1996 Oct;44(10):567-71. doi: 10.1007/s001060050055.
During ENT surgical procedures under general anesthesia contamination of the operating room air through waste anesthetic gases seems unavoidable. A resulting chronic low-level exposure to anesthetic gases in subanesthetic concentrations (m1/m3 = ppm) may cause various negative health effects. The aim of this study was to quantify possible side effects on operating room personnel. By using a highly sensitive, direct reading instrument for determining contamination leakage from a patient's mouth and resulting concentrations in the breathing zone of the surgeon and anesthetist, levels of isoflurane and nitrous oxide were measured at 2-min intervals during 20 ENT surgical procedures performed under usual workplace conditions. Despite high concentrations of anesthetic at the mouth of each patient, personnel-related mean values remained under recommended threshold values (TLV) of 10 ppm isoflurane. A TLV of 100 ppm nitrous oxide was exceeded in 20% of the operations. Furthermore, a safe TLV for pregnant staff was 25 ppm nitrous oxide. This value was exceeded during nearly all operations (93%) for the group "surgeon". High leakages at the patient's mouth led to an undesirably high contamination of operating room personnel by nitrous oxide. Although threshold values were mostly not exceeded in available working conditions (i.e., adequate air conditioning and intubation cuff pressure control), present health and safety regulations concerning pregnant women showed that the values of nitrous oxide were still too high to allow such women to work safely in operating rooms during surgery. However, exposure to isoflurane was too slight to classify.
在全身麻醉下进行耳鼻喉科手术时,手术室空气似乎不可避免地会被废麻醉气体污染。由此导致的长期低水平接触亚麻醉浓度(m1/m3 = ppm)的麻醉气体可能会对健康产生各种负面影响。本研究的目的是量化对手术室工作人员可能产生的副作用。通过使用一种高度灵敏的直读仪器来测定患者口腔的污染泄漏情况以及外科医生和麻醉师呼吸区域的最终浓度,在通常的工作场所条件下进行的20例耳鼻喉科手术过程中,每隔2分钟测量异氟烷和一氧化二氮的水平。尽管每位患者口腔处的麻醉剂浓度很高,但与人员相关的平均值仍低于异氟烷10 ppm的推荐阈值(阈限值)。在20%的手术中,一氧化二氮的阈限值100 ppm被超过。此外,怀孕工作人员的一氧化二氮安全阈限值为25 ppm。在“外科医生”组的几乎所有手术(93%)中,该值都被超过。患者口腔处的高泄漏导致手术室人员被一氧化二氮污染到了不理想的高水平。尽管在现有工作条件下(即,适当的空调和插管袖带压力控制)大多未超过阈值,但现行的关于孕妇的健康与安全规定表明,一氧化二氮的值仍然过高,以至于此类女性无法在手术期间安全地在手术室工作。然而,接触异氟烷的程度太轻微,无法进行分类。