Morinaga T, Furukawa S, Fujii S, Yasuhira K, Watanabe M, Sumi N
Environmental Biological Life Science Research Center Inc., Shiga, Japan.
J Toxicol Sci. 1995 Dec;20 Suppl 2:297-307. doi: 10.2131/jts.20.supplementii_297.
A study of the effect of montirelin hydrate (NS-3), a new drug for the treatment of disturbance of consciousness, during the period of organogenesis was conducted in New Zealand white rabbits. Female rabbits were given the drug intravenously at dose levels of 0 (control), 0.01, 0.1 and 1 mg/kg from day 6 to day 18 of pregnancy. Female rabbits were sacrificed on day 29 of pregnancy for examination of their fetuses. In the 0.1 mg/kg group, food consumption decreased slightly. In the 1 mg/kg group, tachypnea, salivation and rhinorrhea were observed, and body weight and food consumption decreased and water consumption increased. The drug had no effect on the number of corpora lutea and implantations, or on fetal mortality, on fetal body weights, on placental weight, on sex ratio, or on external, visceral and skeletal development of the fetuses. These results show that the NOAEL of montirelin hydrate are 0.1 mg/kg for general toxicity in mother animals, and 1 mg/kg for pregnancy of mother animals and for development of fetuses.
在新西兰白兔中进行了一项关于水合蒙特瑞林（NS - 3）（一种用于治疗意识障碍的新药）在器官形成期作用的研究。从怀孕第6天到第18天，给雌性兔子静脉注射剂量水平为0（对照）、0.01、0.1和1 mg/kg的该药物。在怀孕第29天处死雌性兔子以检查其胎儿。在0.1 mg/kg组中，食物摄入量略有下降。在1 mg/kg组中，观察到呼吸急促、流涎和流鼻涕，体重和食物摄入量下降，而饮水量增加。该药物对黄体数量、着床、胎儿死亡率、胎儿体重、胎盘重量、性别比例或胎儿的外部、内脏和骨骼发育均无影响。这些结果表明，水合蒙特瑞林的无观察到有害作用水平（NOAEL）对于母兽的一般毒性为0.1 mg/kg，对于母兽怀孕和胎儿发育为1 mg/kg。
