Kotschy M, Kałuzny J, Kaniasty M, Zekanowska E, Kropińska E
Katedry i Kliniki Chorób Oczu AM w Bydgoszczy.
Klin Oczna. 1996 Mar;98(3):201-3.
The purpose of the examination was evaluation of tissue plasminogen activator (t-PA) concentration and plasminogen activator inhibitor (PAI) activity in aqueous humor of the eye and plasma of blood in patients operated on cataract.
In aqueous humor and citrate plasma of 24 patients undergoing cataract surgery the concentration of t-PA (Imulyse Biopool) and the activity of PAI-1 (Spectrolyse Biopool) were determined.
In aqueous humor of 90% patients the concentration of t-PA-Ag in mean value 1.5 +/- 2.7 ng/ml was ca 20% of the level present in plasma. In aqueous humor of nearly all patients no PAI-1 activity could be detected. In a little group of persons because of small amounts of aqueous humor, other fibrinolytic parameters were also estimated and the presence of urokinase-type plasminogen activator (u-PA), alfa-2 antiplasmin (alfa-2AP) and plasmin-alfa-2 antiplasmin (PAP) complexes but no activity of protein C were observed.
The presence of PAP complexes in aqueous humor indicates on intensive plasminogenesis in vivo. Our examinations confirm the role of fibrinolytic process in physiological and pathological processes occurring in the eye.
本检查的目的是评估白内障手术患者眼房水和血液血浆中组织型纤溶酶原激活剂（t-PA）浓度及纤溶酶原激活剂抑制剂（PAI）活性。
测定了24例接受白内障手术患者的眼房水和枸橼酸盐血浆中t-PA（Imulyse Biopool）的浓度及PAI-1（Spectrolyse Biopool）的活性。
90%患者的眼房水中t-PA-Ag浓度平均值为1.5±2.7 ng/ml，约为血浆中水平的20%。几乎所有患者的眼房水中均未检测到PAI-1活性。在一小部分因眼房水量少的患者中，还评估了其他纤溶参数，观察到存在尿激酶型纤溶酶原激活剂（u-PA）、α-2抗纤溶酶（α-2AP）和纤溶酶-α-2抗纤溶酶（PAP）复合物，但未观察到蛋白C的活性。
眼房水中存在PAP复合物表明体内纤溶酶生成活跃。我们的检查证实了纤溶过程在眼部发生的生理和病理过程中的作用。
