Grau A, Valls M E, Williams J E, Ellis D S, Muntané M J, Nadal C
Servicio de Medicina Interna, Hospital de Figueres, Girona.
Med Clin (Barc). 1996 Dec 7;107(20):779-81.
The third case in the literature is reported of an infection produced by Pleistophora. The clinical detail of the three cases are discussed. Two of the patients-including the reported one-were infected by HIV. All patients suffered from myositis with fever, resting and at palpation myalgia, and progressive weakness. Blood tests showed anaemia and high levels of muscle enzymes. Necrotic muscle fibrosis induced disabling contractures. Diagnosis was obtained by detecting the protozoon in a muscle biopsy. The spores may be detectable by means of different staining methods at light microscopy although electron microscopy remains the most reliable technique. Since this is such a rare condition there is no known treatment. Whether the albendazole could be as useful as occurs in patients infected by other genera of microsporidia in still uncertain.
本文报道了文献中的第三例由Pleistophora引起的感染病例。讨论了这三例病例的临床细节。其中两名患者(包括本文报道的这例)感染了艾滋病毒。所有患者均患有肌炎,伴有发热、静息和触诊时的肌痛以及进行性肌无力。血液检查显示贫血和肌肉酶水平升高。坏死性肌肉纤维化导致致残性挛缩。通过肌肉活检检测到原生动物得以确诊。尽管电子显微镜检查仍是最可靠的技术,但在光学显微镜下,孢子可通过不同的染色方法检测到。由于这种情况非常罕见,目前尚无已知的治疗方法。阿苯达唑是否能像对其他微孢子虫属感染患者那样有效仍不确定。