Borensztein P, Laghmani K, Froissard M, Paillard M
Unité 356 INSERM, Université Pierre et Marie Curie, Paris.
Nephrologie. 1996;17(7):377-81.
Na+/H+ exchangers (NHE) are plasma transmembrane proteins that exchange extracellular Na+ for intracellular H+. Several isoforms of these antiporters belonging to the same gene family have been cloned and four of them (NHE1 to NHE4) are expressed in the kidney. In the kidney, NHEs isoforms display different tubular and membrane (apical vs basolateral) localization and are involved in different functions: regulation of pH and cell volume, NH4+ secretion and NaHCO3 and NaCl reabsorption. NHE3, which is the apical isoform of the proximal tubule and thick ascending limb of Henle, is involved in bicarbonate reabsorption and displays activation during metabolic acidosis. These recent data showing the acid-activation of NHE3 suggest that NHEs isoforms could be involved in the pathogeny of tubular acidosis.
钠/氢交换体（NHE）是一种血浆跨膜蛋白，可将细胞外的Na⁺与细胞内的H⁺进行交换。这些属于同一基因家族的反向转运蛋白的几种亚型已被克隆，其中四种（NHE1至NHE4）在肾脏中表达。在肾脏中，NHE亚型表现出不同的肾小管和膜（顶端与基底外侧）定位，并参与不同的功能：pH和细胞体积调节、NH₄⁺分泌以及NaHCO₃和NaCl重吸收。NHE3是近端小管和髓袢升支粗段的顶端亚型，参与碳酸氢盐重吸收，并在代谢性酸中毒期间表现出激活。这些显示NHE3酸激活的最新数据表明，NHE亚型可能参与肾小管酸中毒的发病机制。
