Floriańczyk B
Katedra i Zakład Chemii Fizjologicznej Akademii Medycznej w Lublinie.
Postepy Hig Med Dosw. 1996;50(4):375-82.
Metallothioneins are intracellular proteins binding metals. There proteins are involved in zinc and copper homeostasis as well as in organism detoxication of heavy metals. The induction of metallothioneins synthesis is caused not only by metal ions but also by the interleukins, by tumor necrosis factor and by glycocorticoids or the stressing factors. Metallothioneins prove the protective action in cadmium toxication and prevent interaction of cadmium with thiol groups -SH proteins. In neoplasms the increase of metallothionein level occurs both in tumors and in liver, the level of these proteins is correlated with the size of the tumor.
金属硫蛋白是结合金属的细胞内蛋白质。这些蛋白质参与锌和铜的体内平衡以及生物体对重金属的解毒作用。金属硫蛋白合成的诱导不仅由金属离子引起，还由白细胞介素、肿瘤坏死因子、糖皮质激素或应激因素引起。金属硫蛋白在镉中毒中发挥保护作用，并防止镉与巯基-SH蛋白质相互作用。在肿瘤中，肿瘤和肝脏中金属硫蛋白水平都会升高，这些蛋白质的水平与肿瘤大小相关。
