Markov Kh M
Usp Fiziol Nauk. 1996 Oct-Dec;27(4):30-43.
Recent data concerning the physiological, biochemical and pathological aspects of NO and CO in the brain are reviewed. Among them: biosynthesis, regulation and localization of corresponding enzymes (NOS, GO-2) and also cGMP in discrete populations of neurons; interrelationship between glutamate, NMDA-receptors, NO and CO; the role of NO and CO in different physiological and pathological processes in the nervous system, etc. On the basis of data obtained during the last several years, a conception of NO and CO as a novel class of signal molecules operating as neuromediators and/or retrograde transsynaptic messengers is discussed.
本文综述了近期有关大脑中一氧化氮（NO）和一氧化碳（CO）的生理、生化及病理方面的数据。其中包括：相应酶（一氧化氮合酶、鸟苷酸环化酶-2）以及环磷酸鸟苷（cGMP）在离散神经元群体中的生物合成、调节和定位；谷氨酸、N-甲基-D-天冬氨酸受体、NO和CO之间的相互关系；NO和CO在神经系统不同生理和病理过程中的作用等。基于过去几年获得的数据，讨论了将NO和CO视为一类新型信号分子的概念，它们作为神经递质和/或逆向跨突触信使发挥作用。
