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小儿癫痫流行病学:癫痫发作类型与癫痫综合征

[Epidemiology of epilepsy in pediatric age: types of epileptic crises and epileptic syndromes].

作者信息

Ramos Lizana J, Carrasco Marina L, Vázquez López M, Calvo Bonachera C, Cassinello Garcia E

机构信息

Servicio de Pediatría. Hospital Severo Ochoa. Leganes, Madrid.

出版信息

An Esp Pediatr. 1996 Sep;45(3):256-60.

PMID:9019965
Abstract

OBJECTIVES

  1. To study the epidemiological characteristics and types of epileptic seizures in infancy. 2. To evaluate our experience with the ILAE classification of epilepsies and epileptic syndromes and to study the relative frequency of the different epileptic syndromes.

PATIENTS AND METHODS

All patients under 14 years of age that were evaluated for one or more unprovoked seizures in a primary care hospital between January 1, 1988 and June 1, 1994 were prospectively included in the study. In the 151 patients that met these criteria, we studied the epidemiological characteristics, predominantly the type of seizure and the classification as to type of epileptic syndrome.

RESULTS

ETIOLOGY

Of all of the seizures, 18% were considered symptomatic with a predominance in the first three years of life (34%), 28% were idiopathic with the predominance of cases occurring over three years of age (34%) and 54% cryptogenic, with an even distribution in all age groups. 2. Epileptic seizure type: Patients under 3 years old had 17% generalized epilepsies, 20% localization-related, 31% undetermined and 31% isolated seizures. In the 4-9 year olds, had 12%, 51%, 4%, and 32%, respectively. Between 4-14 years of age, benign rolandic epilepsy accounted for 17% of the epilepsies. Sixty-two percent of the patients remained classified in nonspecific categories (26% isolated seizures, 16% undetermined and 20% cryptogenic localization-related).

CONCLUSIONS

The study of unprovoked seizures in children shows marked differences in the different age groups in respect to epileptic seizure type, etiology and epileptic syndrome classification. The application of the ILAE classification system leaves the majority of patients in non-specific categories.

摘要

目的

  1. 研究婴儿期癫痫发作的流行病学特征及类型。2. 评估我们在国际抗癫痫联盟(ILAE)癫痫和癫痫综合征分类方面的经验,并研究不同癫痫综合征的相对频率。

患者与方法

前瞻性纳入1988年1月1日至1994年6月1日期间在一家初级保健医院因一次或多次无诱因发作而接受评估的所有14岁以下患者。在符合这些标准的151例患者中,我们研究了流行病学特征,主要是发作类型和癫痫综合征类型分类。

结果

  1. 病因:在所有发作中,18%被认为是症状性的,在生命的前三年占主导(34%),28%是特发性的,病例主要发生在三岁以上(34%),54%是隐源性的,在所有年龄组中分布均匀。2. 癫痫发作类型:3岁以下患者中,全身性癫痫占17%,局灶性相关癫痫占20%,未分类的占31%,孤立性发作占31%。在4至9岁的患者中,分别为12%、51%、4%和32%。在4至14岁之间,良性罗兰多癫痫占癫痫的17%。62%的患者仍被归类为非特异性类别(26%为孤立性发作,16%未分类,20%为隐源性局灶性相关)。结论:对儿童无诱因发作的研究表明不同年龄组在癫痫发作类型、病因和癫痫综合征分类方面存在显著差异。ILAE分类系统的应用使大多数患者处于非特异性类别。

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