Mattioli F P, Torre G C, Borgonovo G, Arezzo A, Bianchi C, Ughè M
Istituto di Clinica Chirugica Generale e Terapia Chirurgica, Università degli Studi di Genova.
Ann Ital Chir. 1996 May-Jun;67(3):365-71.
Over the last decades definitions and classifications of cervico-mediastinal goiters have been proposed. According to the definition of Valdoni and Tonelli, from 1968 to 1991 237 patients were operated on for cervico-mediastinal goiter. There were 168 simple forms (141 anterior and 27 posterior) and 69 complex forms according to Borrelly's classification. We analyse and discuss the clinical presentation, the diagnostic procedures and the surgical technique in relation to post-operative complications and long term results. The mean duration of symptoms before surgery in patients with cervico-mediastinal goiter was longer than in subjects with cervical goiters. All but 8 operations were performed through a cervical incision. Two patients, both with advanced tumor, died postoperatively. Post-operative complications were: hemorrhage 0.8%, dysphonia 4.6% and transient hypoparathyroidism 2.9%. A clinical follow-up was available for 194 patients. Permanent dyspnea was observed in 1.0%, dysphonia in 4.6% and transient hypoparathyroidism in 2.9%. Tracheotomy was necessary in 5 cases. Complications were more frequent after total thyroidectomy than after partial resection (p < 0.05), after surgery for malignancy than for benign disease (p < 0.05) and in complex than in simple forms (p < 0.05). Almost all cervico-mediastinal goiters can be treated by a cervical incision. Sternotomy, when required, does not influence mobility and mortality. The lacking of an alternative treatment, the relatively high incidence of malignancy and the risk of acute airway obstruction should induce the early removal of all substernal goiters.
在过去几十年里,人们提出了颈纵隔甲状腺肿的定义和分类。根据瓦尔托尼和托内利1968年至1991年的定义,有237例患者接受了颈纵隔甲状腺肿手术。根据博雷利的分类,其中有168例单纯型(141例为前部,27例为后部)和69例复合型。我们分析并讨论了与术后并发症和长期结果相关的临床表现、诊断方法及手术技巧。颈纵隔甲状腺肿患者术前症状的平均持续时间比颈部甲状腺肿患者更长。除8例手术外,其余均通过颈部切口进行。两名患有晚期肿瘤的患者术后死亡。术后并发症包括:出血0.8%、声音嘶哑4.6%、短暂性甲状旁腺功能减退2.9%。对194例患者进行了临床随访。观察到永久性呼吸困难的发生率为1.0%,声音嘶哑为4.6%,短暂性甲状旁腺功能减退为2.9%。5例患者需要行气管切开术。全甲状腺切除术后的并发症比部分切除术后更常见(p<0.05),恶性疾病手术后的并发症比良性疾病手术后更常见(p<0.05),复合型的并发症比单纯型更常见(p<0.05)。几乎所有颈纵隔甲状腺肿都可通过颈部切口进行治疗。需要开胸手术时,并不影响活动能力和死亡率。由于缺乏替代治疗方法、恶性肿瘤相对较高的发生率以及急性气道梗阻的风险,应尽早切除所有胸骨后甲状腺肿。