Ishikawa F
Department of Life Science, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
Biochem Biophys Res Commun. 1997 Jan 3;230(1):1-6. doi: 10.1006/bbrc.1996.5928.
Cancer cells show characteristic telomere dynamics. Their chromosomes usually have short telomeres and a high telomerase activity. The "telomere crisis model" proposed here suggests that these unique telomeric features are responsible for the progression of cancer.
癌细胞表现出独特的端粒动态变化。它们的染色体通常具有短端粒和高端粒酶活性。这里提出的“端粒危机模型”表明，这些独特的端粒特征是癌症进展的原因。
