Czokało M, Pałka M, Kralisz P, Filipkowski T
Department of General and Experimental Pathology, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1996;41(2):417-28.
The concentrations of kininogens, prokallikrein, fibrinogen, plasma protein, proteinase inhibitor antigens, and the kininase, fibrinolytic and antipapain activities in plasma of 29 patients with various tumours (lung cancers, lymphomas, and others) during chemotherapy were measured. The same studies were performed on blood plasma of female patients operated on because of cervical or endometrial carcinoma (37 subjects) and submitted to subsequent local radiotherapy (before and after radiotherapy). A weak activation of kallikrein-kinin system and significant decrease in kininase and fibrinolytic activities were found in those patients. It may suggest a role of bradykinin in prevention of therapy-induced hypercoagulability in patients with neoplastic diseases.
测定了29例患有各种肿瘤（肺癌、淋巴瘤等）的患者在化疗期间血浆中激肽原、前激肽释放酶、纤维蛋白原、血浆蛋白、蛋白酶抑制剂抗原的浓度，以及激肽酶、纤溶和抗木瓜蛋白酶活性。对因宫颈癌或子宫内膜癌接受手术（37例受试者）并随后接受局部放疗（放疗前后）的女性患者的血浆进行了同样的研究。在这些患者中发现激肽释放酶-激肽系统有微弱激活，激肽酶和纤溶活性显著降低。这可能提示缓激肽在预防肿瘤疾病患者治疗诱导的高凝状态中起作用。
