Baako B N, Darko R
Department of Surgery, University of Ghana Medical School, Korle Bu Teaching Hospital, Accra.
West Afr J Med. 1996 Oct-Dec;15(4):223-7.
Helicobacter pylori has been linked with peptic ulcer disease, non-autoimmune gastritis, non peptic ulcer dyspepsia and gastric carcinoma and lymphoma. This study looked at the incidence of H. pylori infection in Ghanaian patients with dyspeptic symptoms referred for upper gastro-intestinal endoscopy and its relationship to various pathologies. Detection was by the CLO urease test. A hundred and thirty (130) patients were studied. 75.4% tested positive for H. pylori infection and the incidence peaks in the 5th decades. While 23.5% H. pylori positive patients had active duodenal or gastric ulcer, 18.8% of H. pylori negative patients also had the ulcer. Out of 43 patients with normal oesophago-gastro-duodenoscopy, 74.4% were H. pylori positive, 66.6% of gastric malignancies tested positive for H. pylori infection. It remains to be confirmed that eradication of H. pylori will relieve the peptic symptoms in affected patients with no ulcer disease.
幽门螺杆菌与消化性溃疡病、非自身免疫性胃炎、非溃疡性消化不良以及胃癌和淋巴瘤有关。本研究观察了因消化不良症状接受上消化道内镜检查的加纳患者中幽门螺杆菌感染的发生率及其与各种病理状况的关系。检测采用CLO尿素酶试验。共研究了130例患者。75.4%的患者幽门螺杆菌感染检测呈阳性，发病率在50多岁时达到峰值。虽然23.5%的幽门螺杆菌阳性患者患有活动性十二指肠或胃溃疡，但18.8%的幽门螺杆菌阴性患者也患有溃疡。在43例食管-胃-十二指肠镜检查正常的患者中，74.4%的患者幽门螺杆菌呈阳性，66.6%的胃恶性肿瘤患者幽门螺杆菌感染检测呈阳性。幽门螺杆菌根除是否能缓解无溃疡病的受影响患者的消化症状仍有待证实。
