Tuzikov A B, Byramova N E, Bovin N V, Gambaryan A S, Matrosovich M N
Shemyakan Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Antiviral Res. 1997 Jan;33(2):129-34. doi: 10.1016/s0166-3542(96)00998-9.
A possible approach to the development of synthetic inhibitors of influenza virus attachment to host cells is based on the anchoring of the minimum receptor determinant of influenza virus, sialic acid, to a polymeric carrier. In this study, the effect of substitution of oxygen by sulphur in the 5N-acetyl moiety of sialic acid on the binding of monovalent and polymeric sialosides by A and B influenza virus strains was investigated. The polymeric inhibitor with pendant 5N-thioacetylneuraminic acid residues was found to be more broadly active against different virus stains that the one prepared from the Neu5Ac ligand.
开发流感病毒与宿主细胞结合的合成抑制剂的一种可能方法是基于将流感病毒的最小受体决定簇唾液酸锚定到聚合物载体上。在本研究中，研究了唾液酸5-N-乙酰基部分中的氧被硫取代对甲型和乙型流感病毒株结合单价和多聚唾液酸苷的影响。发现带有5-N-硫代乙酰神经氨酸残基的聚合物抑制剂对不同病毒株的活性比由Neu5Ac配体制备的抑制剂更广泛。
