小鼠Cdkn2a肿瘤抑制基因的序列变异与染色体定位 - Suppr

Suppr

超能文献

Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene.

作者信息

Herzog C R, You M

机构信息

Department of Pathology, Medical College of Ohio, Toledo 43699, USA.

出版信息

Mamm Genome. 1997 Jan;8(1):65-6. doi: 10.1007/s003359900352.

DOI:10.1007/s003359900352

PMID:9021155

Abstract

摘要

相似文献

Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene.小鼠Cdkn2a肿瘤抑制基因的序列变异与染色体定位

Mamm Genome. 1997 Jan;8(1):65-6. doi: 10.1007/s003359900352.

Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma.胶质瘤中MTS1/p16和MTS2/p15基因的纯合缺失以及CDK4基因的扩增。

Oncogene. 1995 Nov 16;11(10):2145-9.

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.Cdkn2a是细胞周期蛋白依赖性激酶抑制剂，编码p16INK4a和p19ARF，是浆细胞瘤易感位点Pctr1的一个候选基因。

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2429-34. doi: 10.1073/pnas.95.5.2429.

Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas.非典型性和间变性脑膜瘤中肿瘤抑制基因CDKN2A（p16(INK4a)）、p14(ARF)、CDKN2B（p15(INK4b)）和CDKN2C（p18(INK4c)）的改变。

Am J Pathol. 2001 Aug;159(2):661-9. doi: 10.1016/S0002-9440(10)61737-3.

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer.p16（细胞周期蛋白依赖性激酶抑制剂2）是膀胱癌中9p21位点的主要缺失靶点。

Hum Mol Genet. 1995 Sep;4(9):1569-77. doi: 10.1093/hmg/4.9.1569.

Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies.细胞周期蛋白依赖性激酶4抑制剂（p16；MTS1）基因缺失在原发性人类造血系统恶性肿瘤的淋巴样肿瘤中很常见且具有高度特异性。

Blood. 1995 Aug 15;86(4):1548-56.

An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes.小鼠Cdkn2B附近的一个AC重复序列可用于检测肿瘤抑制基因p15INK4b和p16INK4a中的特定等位基因缺失。

Mamm Genome. 1998 Mar;9(3):183-5. doi: 10.1007/s003359900722.

The multiple tumor suppressor 1/cyclin-dependent kinase inhibitor 2 gene in human central nervous system primitive neuroectodermal tumor.

Neurosurgery. 1995 May;36(5):971-4; discussion 974-5. doi: 10.1227/00006123-199505000-00013.

Informative MspI polymorphism adjacent to exon 3 of the p16INK4 (MTS1) gene.与p16INK4（MTS1）基因外显子3相邻的信息性MspI多态性

Mol Cell Probes. 1996 Dec;10(6):467-8. doi: 10.1006/mcpr.1996.0064.

Deletion map of chromosome 9 and p16 (CDKN2A) gene alterations in neuroblastoma.神经母细胞瘤中9号染色体缺失图谱及p16（CDKN2A）基因改变

Cancer Res. 1997 Mar 1;57(5):907-12.

引用本文的文献

A Comprehensive Pan-Cancer Analysis Reveals Cyclin-Dependent Kinase Inhibitor 2A Gene as a Potential Diagnostic and Prognostic Biomarker in Colon Adenocarcinoma.一项全面的泛癌分析揭示细胞周期蛋白依赖性激酶抑制剂2A基因作为结肠腺癌潜在的诊断和预后生物标志物。

Cureus. 2024 May 19;16(5):e60586. doi: 10.7759/cureus.60586. eCollection 2024 May.

CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3.环状 MET 通过增强 CDKN2A mRNA 的衰减和上调 SMAD3 促进肿瘤增殖。

Mol Cancer. 2022 Jan 18;21(1):23. doi: 10.1186/s12943-022-01497-w.

Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells.微阵列分析可区分 L5178Y 小鼠淋巴瘤细胞大、小菌落胸苷激酶突变体的差异基因表达模式。

BMC Bioinformatics. 2006 Sep 6;7 Suppl 2(Suppl 2):S9. doi: 10.1186/1471-2105-7-S2-S9.

Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.利用寡核苷酸阵列鉴定小鼠中的候选肺癌易感基因。

J Med Genet. 2002 Sep;39(9):644-55. doi: 10.1136/jmg.39.9.644.

Mamm Genome. 1998 Mar;9(3):183-5. doi: 10.1007/s003359900722.

本文引用的文献

Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.小鼠肺肿瘤细胞中p15INK4b、p16INK4a-α和p16INK4a-β的纯合共缺失及差异性表达降低

Oncogene. 1996 Nov 7;13(9):1885-91.

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.人类癌症中CDKN2基因体细胞突变的汇编：碱基替换的非随机分布

Genes Chromosomes Cancer. 1996 Feb;15(2):77-88. doi: 10.1002/(SICI)1098-2264(199602)15:2<77::AID-GCC1>3.0.CO;2-0.

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.INK4a肿瘤抑制基因的可变阅读框编码两种能够诱导细胞周期停滞的不相关蛋白质。

Cell. 1995 Dec 15;83(6):993-1000. doi: 10.1016/0092-8674(95)90214-7.

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.细胞周期调控中的一种新调控基序，可特异性抑制细胞周期蛋白D/细胞周期蛋白依赖性激酶4。

Nature. 1993 Dec 16;366(6456):704-7. doi: 10.1038/366704a0.

A cell cycle regulator potentially involved in genesis of many tumor types.一种可能参与多种肿瘤类型发生的细胞周期调节因子。

Science. 1994 Apr 15;264(5157):436-40. doi: 10.1126/science.8153634.

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.多种人类癌症中细胞周期蛋白依赖性激酶4抑制剂基因的缺失。

Nature. 1994 Apr 21;368(6473):753-6. doi: 10.1038/368753a0.

Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors.

Cancer Res. 1994 Aug 1;54(15):4007-10.

Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.

Cancer Res. 1994 Dec 1;54(23):6257-64.

Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB.p16INK4蛋白的缺失仅限于保留野生型RB的肺癌细胞系亚群。

Oncogene. 1994 Nov;9(11):3375-8.

Cloning and characterization of murine p16INK4a and p15INK4b genes.小鼠p16INK4a和p15INK4b基因的克隆与特性分析

Oncogene. 1995 Aug 17;11(4):635-45.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验