Labesse G
Laboratoire de Minéralogie-Cristallographie, Universités Paris 6/Paris 7, CNRS URA 09, France.
Comput Appl Biosci. 1996 Dec;12(6):463-7. doi: 10.1093/bioinformatics/12.6.463.
The protein sequence similarity search has become a major tool for biologists. Various efficient and rapid programs and comparison matrices have been designed and refined in order to perform the scanning task (BLAST, FASTA, Automat, etc.). However, the final step of the search, the analysis of the results, is still tedious and time consuming. In order to optimize true-positive hit screening, we have developed a program which makes a multiple alignment from the BLAST search output. Conserved sequence segments are pointed out. It makes the recognition of already known as well as new sequence patterns easier. It allows at a glance a rapid identification of significant similarities, protein family signature and new sequence motifs. This alignment is written in a compatible format for the GCG programs LineUp and ProfileMake.
蛋白质序列相似性搜索已成为生物学家的主要工具。为了执行扫描任务，人们设计并改进了各种高效、快速的程序和比对矩阵（如BLAST、FASTA、Automat等）。然而，搜索的最后一步，即结果分析，仍然繁琐且耗时。为了优化真阳性命中筛选，我们开发了一个程序，该程序可根据BLAST搜索输出进行多重比对。保守序列片段会被指出。这使得识别已知序列模式和新序列模式变得更加容易。它能让人一眼快速识别出显著的相似性、蛋白质家族特征和新的序列基序。这种比对是以与GCG程序LineUp和ProfileMake兼容的格式编写的。
