Yun J C, Kelly G D, Bartter F C
Can J Physiol Pharmacol. 1977 Aug;55(4):747-54. doi: 10.1139/y77-101.
Infusion of d,l-propranolol in both anesthetized and conscious dogs caused decreases in heart rate (HR), plasma renin activity (PRA), and plasma aldosterone. There was no consistent change in mean arterial blood pressure, plasma renin substrate concentration, packed cell volume, plasma potassium, or plasma sodium concentration following the infusion of propranolol. In five conscious animals, infusion of propranolol (1 mg/kg followed by 0.47-0.65 mg kg-1 h-1) reduced HR from 117.6 +/- 4.0 beats per minute (mean +/- SE) during control periods of 73.2 +/- 2.0 beats per minute (P less than 0.005) 90 min after the start of infusion. PRA decreased from 9.97 +/- 1.79 ng ml-1 h-1 during control periods to reach 1.50 +/- 0.42 ng ml-1 h-1 (P less than 0.005) at the end of the 90-min infusions. Plasma aldosterone also decreased during this time from 17.60 +/- 1.93 ng% during control periods to reach 6.64 +/- 0.98 ng% (P less than 0.005). The data suggest that propranolol at the dose administered suppresses renin and aldosterone secretion in unstimulated dogs. They suggest also that beta-receptor activity contributes to basal renin release.
在麻醉和清醒的犬类中输注消旋普萘洛尔均会导致心率（HR）、血浆肾素活性（PRA）和血浆醛固酮降低。输注普萘洛尔后，平均动脉血压、血浆肾素底物浓度、红细胞压积、血浆钾或血浆钠浓度没有一致的变化。在5只清醒动物中，输注普萘洛尔（1mg/kg，随后以0.47 - 0.65mg·kg⁻¹·h⁻¹）使心率从对照期的117.6±4.0次/分钟降至输注开始90分钟后的73.2±2.0次/分钟（P＜0.005）。PRA从对照期的9.97±1.79ng·ml⁻¹·h⁻¹降至90分钟输注结束时的1.50±0.42ng·ml⁻¹·h⁻¹（P＜0.005）。在此期间，血浆醛固酮也从对照期的17.60±1.93ng%降至6.64±0.98ng%（P＜0.005）。数据表明，所给予剂量的普萘洛尔抑制了未受刺激犬类的肾素和醛固酮分泌。它们还表明β受体活性有助于基础肾素释放。
